Confers
Susceptibility
to Asthma and Atopy
in
Ethnically Diverse Populations
Carole
Ober et al.
Results
of TDT with 2-locus haplotypes and asthma
and
+SPT in the Hutterites
Haplotype 1
is composed of alleles 1-1
Haplotype 2
is composed of alleles 1-2
Haplotype 3
is composed of alleles 2-1
Haplotype 4
is composed of alleles 2-2.
TR = number
of transmitted haplotype
NT = number
of nontransmitted haplotypes
| . |
Asthma
|
+ Skin Prick Test
|
|
TR
|
NT
|
X?
|
TR
|
NT
|
X?
|
| AA
50-375 |
|
11
|
31
|
38
|
0.71
|
119
|
128
|
0.33
|
|
12
|
3
|
8
|
2.27
|
20
|
34
|
3.63
|
|
21
|
41
|
20
|
7.23
|
120
|
91
|
3.99
|
|
22
|
4
|
13
|
4.76
|
39
|
45
|
0.43
|
| AA
50-406 |
|
11
|
33
|
37
|
0.23
|
121
|
131
|
0.40
|
|
12
|
2
|
8
|
3.60
|
19
|
32
|
3.31
|
|
21
|
40
|
23
|
4.59
|
125
|
97
|
3.53
|
|
22
|
5
|
12
|
2.88
|
37
|
42
|
0.32
|
| AA
50-411 |
|
11
|
28
|
38
|
1.52
|
121
|
141
|
1.53
|
|
12
|
1
|
0
|
1.00
|
0
|
1
|
1.00
|
|
21
|
34
|
24
|
1.72
|
132
|
112
|
1.64
|
|
22
|
4
|
5
|
0.11
|
20
|
19
|
0.03
|
| AA
50-478 |
|
11
|
33
|
35
|
0.06
|
118
|
124
|
0.15
|
|
12
|
2
|
10
|
5.33
|
18
|
34
|
4.92
|
|
21
|
36
|
14
|
9.68
|
104
|
82
|
2.60
|
|
22
|
7
|
19
|
5.54
|
58
|
58
|
0.00
|
| AA
50-551 |
|
11
|
34
|
40
|
0.49
|
128
|
142
|
0.73
|
|
12
|
5
|
11
|
2.25
|
33
|
42
|
1.08
|
|
21
|
37
|
16
|
8.32
|
101
|
79
|
2.69
|
|
22
|
9
|
18
|
3.00
|
70
|
69
|
0.01
|
| AA
375-406 |
|
11
|
20
|
5
|
9.00
|
67
|
46
|
3.90
|
|
12
|
1
|
0
|
1.00
|
1
|
4
|
1.80
|
|
21
|
1
|
2
|
0.33
|
4
|
8
|
1.33
|
|
22
|
4
|
19
|
9.78
|
41
|
55
|
20.4
|
| AA
375-411 |
|
11
|
24
|
9
|
6.82
|
87
|
66
|
2.88
|
|
12
|
5
|
5
|
0.00
|
19
|
20
|
0.03
|
|
21
|
4
|
19
|
9.78
|
47
|
67
|
3.51
|
|
22
|
0
|
0
|
0.00
|
0
|
0
|
0.00
|
| AA
375-478 |
|
11
|
27
|
7
|
11.76
|
83
|
62
|
3.04
|
|
12
|
3
|
7
|
1.60
|
17
|
19
|
0.11
|
|
21
|
--
|
--
|
--
|
2
|
6
|
2.00
|
|
22
|
4
|
20
|
10.67
|
43
|
58
|
2.23
|
| AA
375-551 |
|
11
|
28
|
12
|
6.40
|
100
|
88
|
0.77
|
|
12
|
7
|
8
|
0.07
|
41
|
32
|
1.11
|
|
22
|
5
|
20
|
9.00
|
47
|
68
|
3.83
|
| AA
406-411 |
|
11
|
23
|
9
|
6.12
|
79
|
60
|
2.60
|
|
12
|
4
|
5
|
0.11
|
18
|
20
|
0.11
|
|
21
|
5
|
18
|
7.35
|
42
|
59
|
2.86
|
| AA
406-478 |
|
11
|
28
|
8
|
11.11
|
82
|
63
|
2.49
|
|
12
|
4
|
10
|
2.57
|
23
|
26
|
0.18
|
|
21
|
1
|
0
|
1.00
|
1
|
4
|
1.80
|
|
22
|
4
|
19
|
9.78
|
39
|
52
|
1.86
|
| AA
406-551 |
|
11
|
28
|
11
|
7.41
|
99
|
88
|
0.65
|
|
12
|
7
|
10
|
0.53
|
46
|
40
|
0.42
|
|
21
|
1
|
0
|
1.00
|
1
|
4
|
1.80
|
|
22
|
9
|
18
|
3.00
|
41
|
55
|
2.04
|
| AA
406-2531 |
|
11
|
--
|
--
|
--
|
64
|
47
|
2.60
|
|
12
|
--
|
--
|
--
|
5
|
5
|
0.00
|
|
21
|
--
|
--
|
--
|
42
|
59
|
2.86
|
| AA
411-478 |
|
11
|
26
|
7
|
10.94
|
80
|
61
|
2.56
|
|
12
|
4
|
21
|
11.56
|
43
|
61
|
3.12
|
|
21
|
--
|
--
|
--
|
1
|
3
|
1.00
|
|
22
|
3
|
5
|
0.50
|
17
|
16
|
0.03
|
| AA
411-551 |
|
11
|
27
|
11
|
6.74
|
102
|
91
|
0.63
|
|
12
|
6
|
22
|
9.14
|
72
|
82
|
0.65
|
|
21
|
--
|
--
|
--
|
1
|
3
|
1.00
|
|
22
|
5
|
5
|
0.00
|
18
|
17
|
0.03
|
| AA
478-551 |
|
11
|
30
|
9
|
11.31
|
98
|
87
|
0.65
|
|
12
|
2
|
3
|
0.20
|
27
|
21
|
0.75
|
|
21
|
0
|
2
|
2.00
|
0
|
3
|
3.00
|
|
22
|
7
|
25
|
10.12
|
60
|
74
|
1.46
|
Index
of IL4RA Gene results
Complex
Trait Mapping in the Hutterites

|